The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments. Vol 19, No 19 (): MRMC The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry
Mini-Reviews in Medicinal Chemistry - Wikipedia
ISSN Print : ISSN Online : Volume 21, 20 Issues, Download PDF Flyer. Open Access Funding Promote Your Article. ISSN Print : ISSN Online : Co-Editors Atta-ur-RahmanFRS citations Kings College University of Cambridge Cambridge UK Muhammad Iqbal Choudhary citations H. Research Institute of Chemistry University of Karachi Karachi Pakistan Mini reviews in medicinal chemistry Barreca Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Messina Italy.
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Publication in MRMC a well established journal with good impact factor provides a good opportunity for those who want to develop their experience of academic practice and who are seeking professional recognition. I am really impressed with editorial handling and mini reviews in medicinal chemistry reviewing process of our manuscript. Sincere thanks for supportive and constructive comments from the reviewers and editor. It would be our great pleasure to contribute to Pharma society by sharing our knowledge and research experience through MRMC journal in future too.
Neelima Dhingra Assisatant Professor, UIPS,PU Chandigarh, India. Diverse Heterocyclic ring establishes a major portion of organic chemistry works due to its contribution and applications in several fields stretching from insecticides, polymers, agrochemicals, dyes, and abundant, mini reviews in medicinal chemistry.
Many of the biologically important molecules like, vitamins, alkaloids, chlorophyll, nucleic acids, as well as, daily consumed caffeine in tea-coffee and of course majority of the drugs used in the therapy are heterocyclic compounds [1]. Many of the important and distinguished journals pertaining to medicinal and organic chemistry deal with one or the other heterocyclic scaffold every year [2].
The magnitude of research undertaken globally is exponential and the knowledge keeps on expanding. Thus, the information needs to be frequently updated and organized. Therefore, getting updated mini reviews in medicinal chemistry on a range of diverse heterocyclic moieties, compiled and published as special issue like this could be a useful value-addition to the subject and can be used as a source of updated information by many researchers in the field [3].
In this special issue, we have concentrated on quality medicinal chemistry articles focusing on new developments in various therapeutic areas, diverse heterocyclic ring systems [4]. The response to the issue from contributing authors has been heartening and led to 05 quality articles. To accommodate them it has been decided to publish this special issue dealing with their chemistry, synthesis, biological activity spectrum and in few cases even to case studies focused on particular system or biological activity.
A specific paper is for Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules.
In this article the different synthetic pathway for one of the most important and interesting heterocyclic ring systems 1,4-Dihydropyridine. It shows diverse pharmacological action at several receptors, channels, and enzymes.
Another paper is dedicated to systematically evaluation of biological and pharmacological properties of various substituted pyrimidine and collate these findings to be used as a guide for future structure-activity relationship and mode of action studies.
Other review is for systematize the information available in the literature, including patents, regarding the benefits exerted by the combination of these two pharmacophores into single molecules. Another review on updates of new research on tanshinones, focusing in their synthesis, biological activity on noncommunicable diseases and drug delivery systems, in order to support future research on the clinical applications of tanshinones.
The quality publications by the Journal are the result of a joint effort made by a dedicated editorial team members, reviewers and specially authors. We also thank the valuable comments and suggestions given by the reviewers to improve the quality and scientific perspective of the articles. The guest-editor also expresses deep gratefulness to Professors Atta-ur- Rahman, M.
Iqbal Choudhary and Davide Barreca, the Editors-in-Chief of MRMC, and Editorial Advisory Board Members especially Ms. Sara Ariffor their help and support during the preparation of this special issue. The main motivation to prepare for a special issue is the moment of simplicity.
Consensus of simplicity and uncertainty: start of a harmonization or start of mini reviews in medicinal chemistry contradiction? Two complex systems can be united only via a bridge of simplicity.
Medicinal chemistry is a complex phenomenon. Computational chemistry is also a complex phenomenon. The present special issue is an attempt to build up the bridge of simplicity.
The research work is a cutter creating a pattern on the surface of uncertainty. Sometimes the false is hidden near the pattern. Sometimes nature is also hidden near the pattern. Consensus is a word that is originated from medicine. Molecular docking is the basic term of computational chemistry. These conceptions had faced each other here, in this special issue.
Medicinal Chemistry faced electrochemistry; paradigm faced virtual screening; virtual screening faced with multi-scale modeling. The theoretical and practical results of the research activity of a variety of laboratories give the gigantic labyrinth of possible successful applying as well as examples of shocking mistakes sometimes.
The authors of articles of the this special issue provide the reader newest results in the fields where they are working. Every article has history, logic, perspectives and relationship with other articles of the given special issue, mini reviews in medicinal chemistry. The QSPR analysis of the half-wave potentials [2] helps to solve some medicinal tasks. The search of antituberculosis drugs [3] promotes to define a new research direction multi-scale modeling for medicinal chemistry.
Shift of chemistry to biochemistry is typical, mini reviews in medicinal chemistry, but apparently not simple [6], direction. Unexpectedly, here, one can observe shift biochemistry to chemistry. Evolution of research from 2D autocorrelation descriptors [7] to the development of computational methods of controlling behavior of enzymes is interesting. Finally, the physicochemical and biochemical role of surface [8] is especially an important object of both medicinal chemistry and computational chemistry.
Hopefully, interactive learning of the above topics can be an unexpected source of lucky ideas for further research in the field of medicinal chemistry and research in the field of computational chemistry. The guest-editor expresses deep gratitude to all authors who have participated in this special issue. The guest-editor also expresses deep gratefulness to Professors Atta-ur-Rahman, M.
Min-Reviews in Medicinal Chemistry Journal is one of the extremely important and widely circulated journals of Bentham Science Publishers. The current thematic issue has been focused on the role of Phenols and Polyphenols on human health. Phenolic and polyphenolic derivatives constitute an interesting class of synthetic as well as natural organic compounds that possess miraculous antioxidant properties as such because of their ability to quench or reduce the free radicals which are generated due to pro-oxidant-induced oxidative stress which, in turn, accelerate numerous associated chronic diseases.
Additionally, these compounds also act as antibiotics and posses a wide range of biological activity such as anti-cancer, anti-tumor, mini reviews in medicinal chemistry, anti-bacterial, antifungal, mini reviews in medicinal chemistry anti-diarrheal, anti-ulcer, anti-inflammatory activities etc.
In spite of great importance, these compounds also exhibit adverse effects on diverse biological systems particularly when taken in a larger amount. For example, several flavonoid derivatives inhibit thyroid peroxidase an enzyme and thus interfere the biosynthesis of thyroid hormone and ultimately thyroid function.
Tannins, one of mini reviews in medicinal chemistry major polyphenol in foodstuff, when consumed in large amount can lead to formation of tannin-protein complexes, a group of indigestible complexes, inhibit digestive enzymes and affect the utilization of vitamins and minerals.
Among bisphenols, bisphenol A BPA is frequently used to make a hard, clear plastic known as polycarbonate, which has been used in many consumer products including water bottles, baby bottles, metal-based food and beverage cans etc.
FDA also recognized some substantial uncertainties regarding their potential implications for human health effects. A number of reports have shown their toxicity behavior and disclosed the detrimental face of this class of compounds. Therefore, mini reviews in medicinal chemistry, efforts have been made to explore the importance of phenolic compounds in human life and some considerable facts associated to human health through various articles contributed by diverse range of authors.
Here is the brief summary of the six contributed articles: Arbi et al. Their potential to induce skin depigmentation by evaluating their anti-tyrosinase activity has also been explored. In the study, hydroxytamoxifen and some aryl butenes showed strong antiproliferative effects against K cells at 1 μM without showing tyrosinase inhibition and thus have been identified as candidates for further development against chronic myeloid leukemia CMLand are predicted to not induce depigmentation of the skin, a side effect encountered with imatinib [1, 2], a conventionally used drug for the treatment of CML.
Aguilar et al. Health benefits associated with these mini reviews in medicinal chemistry compounds have also been highlighted [4, 5]. Goel et al. The influence of dietary polyphenols on gut microbiota has also been discussed. Thota reviewed on the development of polyphenols as antitumor agents in recent research studies.
Specially, role of polyphenols derived from plant, red wine, black and green tea has been presented []. A diversity of nutritional polyphenolic components in human diet exhibits the great potential of anti inflammatory effects [11].
Some components derived from plants like Resveratrol, Curcumin, Rutin, mini reviews in medicinal chemistry, and Oleocanthal are clinically approved as herbal medicines for traditional use and curing inflammatory disorder such as hepatitis, mini reviews in medicinal chemistry, arthritis, and colitis [], mini reviews in medicinal chemistry.
Kinger et al, mini reviews in medicinal chemistry. Gallic acid 3, 4, 5-trihydroxybenzoic acida low molecular triphenolic compound has arised as an efficient apoptosis inducing agent. The antimicrobial and other biological properties of gallic acid and its derivatives seemed to be linked with the hydrolysis of ester linkage between gallic acid and polyols like tannins hydrolyzed after ripening of many edible fruits [].
Beniwal et al. The quality publications by the Journal are the result of a joint effort made by a dedicated editorial team members, mini reviews in medicinal chemistry, reviewers and authors.
The lead guest editors would like to extend their gratitude to editorial team members and authors of this issue for their valuable scientific contributions. In the end, if you have any suggestion to further improve the journal; please feel free to drop a line to the MRMC.
view more. ISSN Print : ISSN Online : Volume 21, 20 Issues, Download PDF Flyer Open Access Funding Promote Your Article. Ranking and Category: 28 th of 59 in Chemistry, Mini reviews in medicinal chemistry. Atta-ur-RahmanFRS mini reviews in medicinal chemistry Kings College University of Cambridge Cambridge UK.
Muhammad Iqbal Choudhary citations H. Research Institute of Chemistry University of Karachi Karachi Pakistan. Davide Barreca Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Messina Italy. Current: 2. Read More, mini reviews in medicinal chemistry. Issue: 11 [ Issue in Progress ] : This issue is in progress but contains articles that are final and fully citable.
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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry Mini Reviews in Medicinal Chemistry published by Bentham Science Publishers, is of interest to all fraternity from science fields in general and Pharma in specific. Publication in MRMC (a well established journal with good impact factor) provides a good opportunity for those who want to develop their experience of academic practice and who are seeking professional recognition
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